Evaluating Integrative Methods Including Medicinal Cannabis in the Management of Chronic Conditions: A Retrospective Case Series and Prospective Caregiver–Patient Interviews

Summary

Background:

Objective:

To evaluate the use of integrative methods, including medicinal cannabis, in the management of

chronic conditions and to explore patient and caregiver perspectives on clinical outcomes and

treatment challenges.

Methods:

A retrospective case series was conducted using clinical records from an integrative health and

pharmacy practice from eight patients under a Medical Doctor initiated cannabis therapy (2021–

2024). Data included demographics, diagnoses, cannabis formulations, dosing, and clinical

outcomes. Prospective interviews with patients and caregivers captured lived experiences and

perceived benefits. Quantitative data were summarized descriptively, using Microsoft Excel for

MAC version 16.102.3 2025 and the IBM Statistical Package for the Social Sciences Ver. 31 and

qualitative responses were analyzed thematically using QDA Minor 2025 and Powerpoint (ver.

16.107. 2) Word Cloud generator to display the results.

Results:

All patients reported clinical improvements in at least one domain—pain, sleep, appetite,

seizures, behavioral symptoms, or mood. Several patients were able to reduce dosages or

discontinue high-risk medications such as opioids, antipsychotics, and sedatives. Adverse effects

were mild (drowsiness, dry mouth), with no serious events. Caregivers validated improvements

in function, behavior, and patient engagement.

Conclusion:

This case series provides real-world, practice-based evidence supporting the integration of

medicinal cannabis as an adjunct therapy in chronic, refractory conditions. When combined with

holistic interventions—especially nutritional optimization, lifestyle modification, and supportive

mind–body practices—patients experienced meaningful improvements across multiple clinical

domains. These results underscore the value of comprehensive, culturally relevant integrative

care models in emerging healthcare systems and highlight the need for further research to refine

cannabinoid dosing, strengthen evidence-based nutritional strategies, and guide the development

of holistic clinical practice guidelines.